Description

2-Fluoro-5-Hydroxypyridine-4-Boronic Acid is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. This compound matters for its unique molecular architecture, combining a boronic acid group for Suzuki-Miyaura cross-coupling with a fluorinated pyridine core, enabling precise structural modifications in complex molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, as well as by material scientists developing advanced organic electronic components.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used to construct novel fluorinated pyridine derivatives with potential herbicidal or insecticidal activity.
• Material Science: Serves as a precursor for creating functionalized polymers and ligands for metal-organic frameworks (MOFs) or catalysts.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality enables efficient carbon-carbon bond formation to create complex biaryl structures under mild conditions.
• Chemical Biology Probes: Utilized in the development of fluorinated molecular probes and tags for studying biological processes.
• Ligand Synthesis: Acts as a starting material for preparing specialized bidentate or tridentate ligands in coordination chemistry.

Basic Information

Product Name	2-Fluoro-5-Hydroxypyridine-4-Boronic Acid
CAS No.	2121511-39-3
Molecular Formula	C5H5BFNO3
Molecular Weight	156.91 g/mol
Synonyms	(2-Fluoro-5-hydroxypyridin-4-yl)boronic acid; 4-Borono-2-fluoro-5-hydroxypyridine; 2-Fluoro-5-hydroxy-4-pyridineboronic acid; 5-Hydroxy-2-fluoropyridine-4-boronic acid; 2-Fluoro-5-hydroxypyridine-4-borononic acid; 4-Pyridineboronic acid, 2-fluoro-5-hydroxy-; 2121511-39-3
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Hydroxypyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.