Description

Phosphine, Dicyclohexyl[3-(1-Methylethoxy)-2',4',6'-Tris(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]- is a sophisticated, sterically hindered phosphine ligand designed for advanced catalytic applications. This compound matters because it provides exceptional stability and selectivity in transition metal-catalyzed cross-coupling reactions, a cornerstone of modern pharmaceutical and fine chemical synthesis. Chemical manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty materials sectors need this high-performance ligand to develop novel compounds and optimize complex synthetic pathways.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for constructing C-N and C-C bonds.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective production of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Product Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring precise molecular architecture.
• Material Science Research: Facilitates the creation of novel organic electronic materials, polymers, and ligands for metal-organic frameworks (MOFs).
• Asymmetric Catalysis: Potential use in developing chiral catalysts for the production of enantiomerically pure compounds.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new chemical spaces in synthetic chemistry laboratories.

Basic Information

Product Name	Phosphine, Dicyclohexyl[3-(1-Methylethoxy)-2',4',6'-Tris(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]-
CAS No.	2118959-55-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine; cataCXium P; BrettPhos Precursor Ligand; 2-(Dicyclohexylphosphino)-3,6-diisopropoxy-2',4',6'-triisopropyl-1,1'-biphenyl; Biarylphosphine Ligand; Buchwald Phosphine Ligand; Sterically Hindered Trialkylphosphine
EINECS	Contact for details

Quality Control

Every batch of our phosphine ligand undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive catalytic applications. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment to guarantee batch-to-batch consistency and support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized; prolonged exposure to air must be avoided to maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.