Description

Dspe-Peg8-Mal is a heterobifunctional polyethylene glycol (PEG) derivative featuring a DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) lipid anchor and a maleimide (Mal) reactive group, connected by an 8-unit PEG spacer. This compound is engineered for the precise conjugation of biomolecules, enabling the creation of stable, functionalized lipid-based assemblies. It is a critical reagent for researchers and developers in the fields of nanomedicine, targeted drug delivery, and diagnostic probe development. The product is supplied as a high-purity material to ensure reliable and reproducible results in sensitive bioconjugation workflows.

Application

• Lipid Nanoparticle (LNP) Functionalization: Conjugation of targeting ligands (e.g., antibodies, peptides) or imaging agents to the surface of LNPs for targeted drug delivery.
• PEGylated Liposome Engineering: Site-specific attachment of thiol-containing molecules to create stealth liposomes with enhanced circulation time and active targeting capabilities.
• Bioconjugation & Probe Synthesis: Covalent linkage of proteins, peptides, or oligonucleotides containing free thiol groups for the preparation of diagnostic or therapeutic conjugates.
• Surface Modification of Nanocarriers: Functionalizing micelles, polymersomes, or other nanocarriers derived from DSPE-PEG for specific biomedical applications.
• Biomaterial Coating: Creating biofunctional surfaces on materials by incorporating the maleimide group for subsequent thiol-based immobilization of biomolecules.
• Research & Development: A versatile tool in R&D for exploring novel drug delivery systems and bioconjugation strategies in academic and industrial settings.

Basic Information

Product Name	Dspe-Peg8-Mal
CAS No.	2112737-94-5
Molecular Formula	C95H185N2O38P
Molecular Weight	~2000.5 g/mol (average)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; DSPE-PEG(2000) Maleimide; DSPE-PEG2k-Mal; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-PEG8-Maleimide; DSPE-PEG-Maleimide (MW 2000); Phospholipid-PEG-Maleimide; Maleimide-PEG-DSPE; Lipid-PEG-Mal
EINECS	Contact for details

Quality Control

Our Dspe-Peg8-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Key quality parameters, including assay by NMR, maleimide activity, and critical impurity profiles, are verified. Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White or off-white solid/waxy solid
Identification (NMR)	Complies with structure
Assay (Purity by NMR)	≥ 95%
Maleimide Functionalization	≥ 90%
Molecular Weight (Average)	2000 ± 100 Da
Solubility	Soluble in chloroform, DMSO, DMF; forms micelles in water
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.