Description

n-(Aminooxy-Peg3)-n-Bis(Peg4-T-Butyl Ester) is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring an aminooxy group and two terminal tert-butyl ester-protected carboxylic acids. This compound is engineered as a high-value linker for advanced bioconjugation and chemical biology applications, enabling the controlled assembly of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, diagnostic agents, and sophisticated drug delivery systems.

Application

• Bioconjugation Reagent: Used for site-specific protein and antibody modification via oxime ligation with ketone or aldehyde functionalities.
• PEGylation Linker: Serves as a key intermediate for creating branched or multi-arm PEG structures to enhance the pharmacokinetic properties of therapeutic proteins and peptides.
• Drug Delivery System Synthesis: Facilitates the construction of complex, stimuli-responsive drug carriers and nanomedicines.
• Crosslinking Agent: Enables the formation of hydrogels and biomaterial scaffolds for tissue engineering and 3D cell culture applications.
• Diagnostic Probe Development: Employed in the synthesis of labeled probes and imaging agents for molecular diagnostics and in vivo imaging.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile building block for introducing PEG spacers and functional handles during peptide synthesis.

Basic Information

Product Name	n-(Aminooxy-Peg3)-n-Bis(Peg4-T-Butyl Ester)
CAS No.	2112737-19-4
Molecular Formula	C41H79N3O18
Molecular Weight	902.1 g/mol
Synonyms	1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid, 27-[(1,1-dimethylethoxy)carbonyl]-29-[(1,1-dimethylethoxy)carbonyl]-28-oxo-, 2-oxime; Aminooxy-PEG3-tris-(PEG4-t-butyl ester); (Aminooxy)tri(ethylene glycol)-tris[11-(tert-butoxy)-3,6,9-trioxa-11-oxoundecyl]amine; Heterobifunctional PEG linker, Aminooxy-PEG3, Bis(PEG4-t-butyl ester); O-(2-Aminooxyethyl)-O'-(2-{2-[2-(2-{2-[2-(2-{2-[2-(tert-butoxy)-2-oxoethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl) N-[2-(2-{2-[2-(2-{2-[2-(tert-butoxy)-2-oxoethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl]iminodiacetate
EINECS	Contact for details

Quality Control

Our n-(Aminooxy-Peg3)-n-Bis(Peg4-T-Butyl Ester) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.