Description

n-Dbco-n-Bis(Peg2-Acid) CAS NO 2110449-00-6 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group and two carboxylic acid termini. This compound is engineered for high-efficiency, copper-free click chemistry conjugation, enabling the stable and specific labeling of biomolecules under mild, physiological conditions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs) and diagnostic reagents.

Application

• Copper-free click chemistry for bioconjugation and labeling of proteins, peptides, and antibodies.
• Synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Surface functionalization of nanoparticles and biomaterials for diagnostic and therapeutic applications.
• Preparation of PEGylated reagents and crosslinkers for modifying biomolecule solubility and pharmacokinetics.
• Development of biosensors and immunoassay components through site-specific immobilization.
• Proteomics research, including the tagging and enrichment of specific biomolecules.

Basic Information

Product Name	n-Dbco-n-Bis(Peg2-Acid)
CAS No.	2110449-00-6
Molecular Formula	C31H38N2O10
Molecular Weight	598.65 g/mol
Synonyms	DBCO-PEG2-acid-COOH; DBCO-PEG2-Bis(carboxylic acid); Dibenzocyclooctyne-PEG2-diacid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11-tetraoxatetradecane-14,14-diyl) diacetate; 2,5,8,11-Tetraoxatetradecanedioic acid, 14,14'-[(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethylene] ester; Heterobifunctional DBCO-PEG linker; Azadibenzocyclooctyne-PEG2-diacid; DBCO-acid-PEG2-acid
EINECS	Contact for details

Quality Control

Our n-Dbco-n-Bis(Peg2-Acid) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.