Description

Boc-Gly-Peg3-Endo-Bcn CAS NO 2110444-63-6 is a specialized bifunctional linker molecule featuring a Boc-protected glycine, a triethylene glycol (PEG3) spacer, and an endo-BCN (bicyclo[6.1.0]nonyne) group. This compound is engineered for high-efficiency, copper-free click chemistry applications, enabling the precise conjugation of biomolecules under mild, physiological conditions. It is an essential reagent for researchers and developers in bioconjugation, proteomics, antibody-drug conjugate (ADC) development, and advanced materials science, where site-specific labeling and controlled assembly are critical.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of antibodies, peptides, and other proteins via strain-promoted azide-alkyne cycloaddition (SPAAC) with azide-functionalized molecules.
• Antibody-Drug Conjugate (ADC) Development: Facilitating the construction of homogeneous, stable ADCs by linking cytotoxic payloads to monoclonal antibodies.
• Proteomics and Biomarker Discovery: Immobilization of bait molecules on solid supports for affinity purification and pull-down assays.
• Chemical Biology Tool Development: Synthesis of activity-based probes and imaging agents for studying biological processes in live cells.
• Polymer and Materials Science: Surface functionalization of nanoparticles, hydrogels, and diagnostic devices to introduce bio-recognition elements.
• Diagnostic Assay Development: Conjugation of detection labels (e.g., fluorophores, enzymes) to antibodies or oligonucleotides for ELISA, lateral flow, and other diagnostic platforms.

Basic Information

Product Name	Boc-Gly-Peg3-Endo-Bcn
CAS No.	2110444-63-6
Molecular Formula	C27H44N2O8
Molecular Weight	524.65 g/mol
Synonyms	Boc-Gly-PEG3-endo-BCN; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-(2-(2-(2-((tert-butoxycarbonyl)amino)acetamido)ethoxy)ethoxy)ethyl)carbamate; tert-Butyl (2-(2-(2-((((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methoxy)carbonyl)amino)ethoxy)ethoxy)ethyl)glycinate; BCN-PEG3-Gly-Boc; Endo-BCN-PEG3-Glycine-Boc; BCN-PEG3-Glycine tert-Butyl Ester; Copper-free Click Chemistry Linker BCN-PEG3-Gly-Boc
EINECS	Contact for details

Quality Control

Our Boc-Gly-Peg3-Endo-Bcn is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.