Description

Endo-Bcn-Peg3-Nhs Ester is a heterobifunctional crosslinking reagent featuring an endo-BCN group and an amine-reactive NHS ester, connected by a hydrophilic triethylene glycol (PEG3) spacer. This compound is essential for bioorthogonal click chemistry applications, enabling efficient and specific conjugation of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs) and diagnostic probes.

Application

• Site-specific bioconjugation and labeling of proteins, peptides, and antibodies.
• Synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Preparation of fluorescent or affinity probes for cellular imaging and proteomics studies.
• Surface functionalization of nanoparticles and materials for biomedical applications.
• Construction of protein-protein or protein-small molecule complexes for structural biology.
• Development of diagnostic assays and biosensors utilizing click chemistry.
• Polymer modification to introduce bioorthogonal handles for further derivatization.
• Ligation strategies in chemical biology for studying biomolecular interactions.

Basic Information

Product Name	Endo-Bcn-Peg3-Nhs Ester
CAS No.	2101206-94-2
Molecular Formula	C₂₄H₃₈N₂O₈
Molecular Weight	482.57 g/mol
Synonyms	endo-BCN-PEG3-NHS Ester; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,5,8,11-tetraoxatetradecan-14-oate 2,5-dioxopyrrolidin-1-yl ester; 1-[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl]methyl 3-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]propanoate; BCN-PEG3-NHS; endo-BCN-PEG3-OSu; BCN-PEG3-NHS Ester; endo-BCN-PEG3-N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg3-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.