Description

3',3'-Difluoro-1,4'-Bipiperidine Dihydrochloride is a high-purity, fluorinated bipiperidine derivative supplied as a dihydrochloride salt. This compound serves as a critical pharmaceutical intermediate and building block in modern organic synthesis, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and fungicides containing fluorinated piperidine motifs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand Development: Utilized for creating novel ligands and catalysts in asymmetric synthesis and metal-organic frameworks.

Basic Information

Product Name	3',3'-Difluoro-1,4'-Bipiperidine Dihydrochloride
CAS No.	2101206-90-8
Molecular Formula	C10H18F2N2 · 2HCl
Molecular Weight	281.18 g/mol (Free base: 204.26 g/mol)
Synonyms	1,4'-Bipiperidine, 3',3'-difluoro-, dihydrochloride; 3,3-Difluoro-1,4'-bipiperidine dihydrochloride; 3',3'-Difluoro-[1,4']bipiperidinyl dihydrochloride; 3,3-Difluorobipiperidine dihydrochloride; 3-Fluoro-4-(3-fluoropiperidin-1-yl)piperidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 3',3'-Difluoro-1,4'-Bipiperidine Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.