Description

Perfluorophenyl 3-(2-(2-(2-(1,3-Dioxoisoindolin-2-Yloxy)Ethoxy)Ethoxy)Ethoxy)Propanoate is a specialized bifunctional chemical building block designed for advanced material synthesis. Its core value lies in the unique combination of a perfluorophenyl active ester group and a phthalimide-protected poly(ethylene glycol) (PEG) linker, enabling precise conjugation and functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require high-purity, reactive intermediates for developing targeted drug delivery systems, diagnostic agents, and functional polymers.

Application

• Bioconjugation Reagent: Used for the site-specific modification of peptides, proteins, and antibodies via its reactive perfluorophenyl ester group.
• PEGylation Linker: Serves as a key intermediate for introducing hydrophilic PEG spacers to enhance the solubility, stability, and pharmacokinetics of therapeutic molecules.
• Polymer Functionalization: Enables the controlled functionalization of polymer backbones to create smart materials with tailored properties for biomedical applications.
• Prodrug Synthesis: Facilitates the development of prodrugs by linking active pharmaceutical ingredients (APIs) to cleavable PEG-based promoieties.
• Surface Modification: Applied in coating technologies to modify material surfaces with bio-inert or bioactive PEG layers, reducing non-specific binding.
• Diagnostic Probe Development: Utilized in the synthesis of contrast agents and fluorescent probes for imaging and diagnostic assays.

Basic Information

Product Name	Perfluorophenyl 3-(2-(2-(2-(1,3-Dioxoisoindolin-2-Yloxy)Ethoxy)Ethoxy)Ethoxy)Propanoate
CAS No.	2101206-87-3
Molecular Formula	C25H22F5NO9
Molecular Weight	575.44 g/mol
Synonyms	PFP-PEG4-PI; Pentafluorophenyl-PEG4-phthalimide; 2,3,4,5,6-Pentafluorophenyl 3,6,9,12-tetraoxa-2-aza-15-phthalimidopentadecanoate; 15-Phthalimido-4,7,10,13-tetraoxapentadecanoic Acid Pentafluorophenyl Ester; PFP-PEG4-Phthalimide; PFP-PEG4-NHPI; PFP-PEG4-OSu (related analog); Pentafluorophenyl ester of PEG4-phthalimide
EINECS	Contact for details

Quality Control

Our Perfluorophenyl 3-(2-(2-(2-(1,3-Dioxoisoindolin-2-Yloxy)Ethoxy)Ethoxy)Ethoxy)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is moisture-sensitive and should be handled under dry conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.