Description

Perfluorophenyl 1-(1,3-Dioxoisoindolin-2-Yloxy)-3,6,9,12-Tetraoxapentadecan-15-Oate is a specialized bifunctional chemical building block that combines a perfluorinated aromatic moiety with a hydrophilic polyethylene glycol (PEG) linker terminated by a phthalimide-protected hydroxyl group. This unique structure makes it a valuable intermediate for the synthesis of advanced materials and functional molecules, offering precise control over solubility, reactivity, and surface properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, materials science, and specialty chemical sectors for applications requiring fluorinated components with enhanced aqueous compatibility.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly for creating prodrugs or conjugates that leverage the perfluorophenyl group for selective reactions and the PEG spacer for improved pharmacokinetics.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for developing fluorinated polymers, coatings, and hydrogels with unique hydrophobic/hydrophilic balance, chemical resistance, and low surface energy.
• Bioconjugation & Probe Synthesis: Acts as a versatile linker for attaching fluorophores, peptides, or other bioactive molecules to surfaces, nanoparticles, or polymers, facilitated by the reactive perfluorophenyl ester and protected amine (after deprotection of phthalimide).
• Surface Modification: Employed to functionalize materials like silica, metals, or polymers to impart specific surface characteristics, such as anti-fouling properties or tailored wettability.
• Liquid Crystal & Electronic Material Precursor: Utilized in the design of fluorinated organic semiconductors or liquid crystal compounds where the combination of fluorine and PEG chains modulates self-assembly and electronic properties.
• Research & Development: A key reagent in academic and industrial R&D for exploring new chemical entities in medicinal chemistry, supramolecular chemistry, and nanotechnology.

Basic Information

Product Name	Perfluorophenyl 1-(1,3-Dioxoisoindolin-2-Yloxy)-3,6,9,12-Tetraoxapentadecan-15-Oate
CAS No.	2101206-46-4
Molecular Formula	C₃₁H₂₄F₅NO₁₀
Molecular Weight	665.52 g/mol
Synonyms	PFP-PEG4-Phthalimide; Pentafluorophenyl-PEG4-phthalimide ester; 2,3,4,5,6-Pentafluorophenyl 1-(1,3-dioxoisoindolin-2-yloxy)-3,6,9,12-tetraoxapentadecan-15-oate; 15-((2,3,4,5,6-Pentafluorophenoxy)carbonyl)-3,6,9,12-tetraoxapentadecyl phthalimide; PFP-PEG4-NHP; Perfluorophenyl ester of PEG4-phthalimide; F₅PhO-PEG4-NHP
EINECS	Contact for details

Quality Control

Our production of Perfluorophenyl 1-(1,3-Dioxoisoindolin-2-Yloxy)-3,6,9,12-Tetraoxapentadecan-15-Oate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be kept under inert atmosphere for long-term storage to maximize stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.