Description

Nh-Bis(Peg2-Propargyl) CAS NO 2100306-83-8 is a specialized bifunctional PEG linker featuring terminal propargyl groups, designed for advanced bioconjugation and materials science applications. This compound is critical for enabling precise, site-specific coupling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and the creation of functionalized hydrogels and polymers.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides with fluorophores, drugs, or other functional molecules.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a cleavable or non-cleavable spacer to connect cytotoxic payloads to monoclonal antibodies.
• Polymer and Dendrimer Synthesis: Acts as a versatile building block for creating functionalized PEG-based polymers, dendrimers, and cross-linked networks.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and microarray surfaces with alkyne groups for subsequent bio-immobilization.
• Hydrogel Formation: A key cross-linking agent in the development of biocompatible hydrogels for drug delivery and tissue engineering.
• Chemical Probe Development: Enables the synthesis of activity-based probes for studying enzyme function and protein-protein interactions.

Basic Information

Item	Details
Product Name	Nh-Bis(Peg2-Propargyl)
CAS No.	2100306-83-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,11-Bis(prop-2-yn-1-yloxy)-3,6,9-trioxaundecane; Bis(PEG2-propargyl)amine; α,ω-Bis(propargyl)-PEG2; Propargyl-PEG2-NH-PEG2-propargyl; NH-Bis(PEG2-Propargyl) Ether; 3,6,9-Trioxaundecane-1,11-diyl bis(2-propynyl) ether; Bifunctional PEG2 Alkyne Linker
EINECS	Contact for details

Quality Control

Our Nh-Bis(Peg2-Propargyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.