Description

n-(Biotin)-n-Bis(Peg1-Alcohol) CAS NO 2100306-75-8 is a specialized bifunctional PEG derivative featuring a biotin moiety and two terminal hydroxyl groups, designed for advanced bioconjugation and linker applications. This compound is engineered to provide a versatile and reliable bridge for attaching biomolecules, nanoparticles, or surfaces via the high-affinity biotin-streptavidin interaction, while the PEG spacer offers enhanced solubility and reduced immunogenicity. It is a critical reagent for researchers and manufacturers in the fields of diagnostic assay development, targeted drug delivery systems, and advanced materials science.

Application

• Diagnostic Reagent Conjugation: Used as a linker to attach antibodies, enzymes, or other detection molecules to solid supports (e.g., microplates, beads) in ELISA, lateral flow assays, and biosensors.
• Drug Delivery & Nanomedicine: Facilitates the surface functionalization of liposomes, polymeric nanoparticles, or dendrimers with targeting ligands via biotinylation for active targeting strategies.
• Affinity Chromatography & Purification: Serves as a spacer arm for immobilizing biotinylated ligands onto streptavidin/avidin resins for the capture and purification of specific biomolecules.
• Biomaterials & Surface Engineering: Enables the controlled bio-functionalization of surfaces (e.g., gold chips, glass slides) for cell culture studies, microarray technology, and implant coatings.
• Chemical Biology & Proteomics: Acts as a versatile tool for cross-linking, labeling, or pull-down experiments in studying protein-protein interactions and cellular pathways.
• ADC (Antibody-Drug Conjugate) Development: Provides a modular platform for constructing cleavable or non-cleavable linkers between antibodies and payloads in ADC research.

Basic Information

Item	Detail
Product Name	n-(Biotin)-n-Bis(Peg1-Alcohol)
CAS No.	2100306-75-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Biotin-PEG2-diol; 1,8-Bis(2-hydroxyethoxy)-3,6-dioxaoctane-1,8-diyl biotin; Biotinylated PEG diol; Biotin-PEG2-(OH)2; Biotin-ethylene glycol dimer alcohol; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pentanamide; Biotin-amido-PEG2-alcohol
EINECS	Contact for details

Quality Control

Our n-(Biotin)-n-Bis(Peg1-Alcohol) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.