Description

Benzyloxy Carbonyl-Peg3-Nhs Ester CAS NO 2100306-68-9 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a benzyloxycarbonyl (Cbz) protected amine. This compound matters for its role as a critical reagent in bioconjugation and peptide synthesis, enabling the controlled, site-specific coupling of biomolecules. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and advanced biomaterials.

Application

• Bioconjugation Reagent: For the covalent attachment of peptides, proteins, or antibodies to other molecules, surfaces, or nanoparticles via its NHS ester group.
• Peptide Synthesis Intermediate: Used in solid-phase peptide synthesis (SPPS) as a building block, where the Cbz group serves as a temporary amine protecting group.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the creation of linker-payload constructs, connecting cytotoxic drugs to monoclonal antibodies with a PEG spacer for improved solubility and pharmacokinetics.
• PEGylation Chemistry: Serves as a functionalized PEG spacer to introduce hydrophilic polyethylene glycol chains onto drugs or proteins, enhancing their stability and circulation time.
• Surface Functionalization: Employed to modify materials (e.g., gold, silica) or sensor surfaces with amine-reactive groups for biosensor and microarray applications.
• Polymer and Dendrimer Synthesis: Acts as a monomer or crosslinking agent in the synthesis of functionalized polymers and dendritic structures for drug delivery systems.

Basic Information

Product Name	Benzyloxy Carbonyl-Peg3-Nhs Ester
CAS No.	2100306-68-9
Molecular Formula	C24H34N2O9
Molecular Weight	494.54 g/mol
Synonyms	N-(Benzyloxycarbonyl)-3,6,9-trioxaundecanedioic acid 11-(2,5-dioxo-1-pyrrolidinyl) ester; Cbz-NH-PEG3-NHS ester; Z-PEG3-NHS; Benzyl N-[2-[2-[2-[2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethoxy]ethoxy]ethyl]carbamate; Carbobenzoxy-PEG3-NHS; Nα-Cbz-8-amino-3,6-dioxaoctanoic acid N-hydroxysuccinimide ester; Cbz-8-amino-3,6-dioxaoctanoic acid NHS ester; Z-8-Amino-3,6-dioxaoctanoic Acid Succinimidyl Ester
EINECS	Contact for details

Quality Control

Our Benzyloxy Carbonyl-Peg3-Nhs Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. For long-term stability, store in a freezer and allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.