Description

n-(Propargyl-Peg2)-n-Bis(Peg1-Alcohol) is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a propargyl group and two hydroxyl termini, making it a versatile building block for advanced bioconjugation and materials science. This compound is essential for researchers and manufacturers requiring precise, modular assembly of complex molecular architectures, particularly in aqueous environments. Its primary value lies in enabling click chemistry via the alkyne handle while providing hydrophilic PEG spacers and alcohol groups for further functionalization, which is critical for developing targeted drug delivery systems, diagnostic probes, and functional hydrogels.

Application

• Bioconjugation & Linker Chemistry: Serves as a key heterobifunctional crosslinker for attaching biomolecules (e.g., proteins, peptides, oligonucleotides) to surfaces, nanoparticles, or other polymers via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of linker-payload constructs, where the PEG chain enhances solubility and pharmacokinetics, and the propargyl group allows for site-specific conjugation to azide-modified antibodies or toxins.
• Polymer & Hydrogel Synthesis: Acts as a functional monomer or crosslinking agent for creating PEG-based hydrogels and smart materials with tunable properties for biomedical applications like tissue engineering scaffolds and controlled release matrices.
• Diagnostic Reagent Formulation: Employed to functionalize dyes, contrast agents, or quantum dots with PEG chains, improving their biocompatibility, stability, and targeting capability for in vitro and in vivo imaging.
• Surface Modification & Functionalization: Utilized to create hydrophilic, bio-inert coatings on medical devices, biosensors, and chromatography media by grafting via the hydroxyl or alkyne groups.
• Prodrug Synthesis: Facilitates the design of prodrugs where therapeutic agents are conjugated via a cleavable linker to the PEG-alcohol scaffold, enhancing drug solubility and circulation time.

Basic Information

Product Name	n-(Propargyl-Peg2)-n-Bis(Peg1-Alcohol)
CAS No.	2100306-62-3
Molecular Formula	C11H20O5
Molecular Weight	232.27 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadec-14-yn-15-ol; Propargyl-PEG2-bis(PEG1-alcohol); 2,2'-(2-(Prop-2-yn-1-yloxy)ethylazanediyl)di(ethan-1-ol); 2-[2-(Prop-2-yn-1-yloxy)ethylamino]diethanol; N-(Propargyl-triethylene glycol)-N-bis(ethylene glycol); Heterobifunctional PEG Alkyne Diol; Alkyne-PEG2-bis(hydroxyethyl)amine; Click Chemistry PEG Linker
EINECS	Contact for details

Quality Control

Our n-(Propargyl-Peg2)-n-Bis(Peg1-Alcohol) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with customer requirements for advanced organic synthesis and bioconjugation. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.