Description

Alkyne-Ethyl-Peg1-T-Butyl Ester is a specialized bifunctional chemical building block designed for advanced organic synthesis. This compound is valued for its unique structure, which incorporates both a terminal alkyne group and a protected carboxylic acid moiety, enabling precise conjugation and polymer modification reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, bioconjugation, and materials science industries to develop novel drug candidates, diagnostic probes, and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted drug delivery systems and antibody-drug conjugates (ADCs).
• Bioconjugation & Click Chemistry: The terminal alkyne group facilitates efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for labeling biomolecules like proteins, peptides, and oligonucleotides.
• Polymer & Materials Science: Used to introduce functional handles into polymer backbones or surfaces for creating smart materials, hydrogels, and surface coatings with tailored properties.
• Proteomics Research: Enables the site-specific modification of proteins for activity-based protein profiling (ABPP) and other chemical proteomics applications.
• Diagnostic Reagent Synthesis: Serves as a precursor for fluorescent dyes, imaging agents, and other diagnostic tools requiring stable linker chemistry.
• Chemical Biology Tool Development: Employed in creating molecular probes to study biological pathways and enzyme functions within living systems.

Basic Information

Product Name	Alkyne-Ethyl-Peg1-T-Butyl Ester
CAS No.	2100306-55-4
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	2-[2-(2-Prop-2-ynoxyethoxy)ethoxy]acetic acid tert-butyl ester; Propargyl-PEG1-t-butyl ester; Tert-Butyl 2-[2-(2-prop-2-yn-1-yloxyethoxy)ethoxy]acetate; Alkyne-PEG1-t-butyl ester; 2,5,8-Trioxa-11-dodecynoic acid, 12-tert-butyl ester; TBDMS Alkyne-PEG1-COOH; Alkyne-PEG1-acid t-butyl ester; Propargyl-O1-(t-butyl acetate)-O2-ethyleneglycol
EINECS	Contact for details

Quality Control

Our Alkyne-Ethyl-Peg1-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research and cGMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.