Description

n-(Amino-Peg1)-n-Bis(Peg2-Propargyl) Hcl Salt is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a primary amine and two propargyl groups, presented as its hydrochloride salt for enhanced stability. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise, high-yield attachment of biomolecules, polymers, or small molecules. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-purity linkers for creating complex molecular architectures like antibody-drug conjugates (ADCs) and hydrogel networks.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: The amine group allows for coupling to carboxylates or carbonyls on antibodies, while the propargyl groups enable copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry with azide-functionalized payloads.
• Polymer and Dendrimer Synthesis: Serves as a versatile branching unit or initiator for constructing PEG-based polymers, star polymers, and dendrimers with controlled architecture and functionality.
• Surface Functionalization and Material Science: Used to modify surfaces (e.g., nanoparticles, chips, beads) with amine and alkyne handles for subsequent immobilization of biomolecules or creation of functional coatings.
• Proteomics and Biomolecule Crosslinking: Facilitates the site-specific crosslinking or labeling of proteins, peptides, and oligonucleotides for structural studies, diagnostics, or therapeutic applications.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinker in the formation of biocompatible PEG hydrogels for drug delivery systems, tissue engineering scaffolds, and 3D cell culture matrices.
• Chemical Biology Probe Development: Enables the synthesis of activity-based probes or affinity tags for target identification and validation in drug discovery pipelines.

Basic Information

Item	Details
Product Name	n-(Amino-Peg1)-n-Bis(Peg2-Propargyl) Hcl Salt
CAS No.	2100306-47-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Amino-3,6,9,12-tetraoxapentadec-14-yn-15-yl 2,5,8,11-tetraoxatetradec-13-yn-14-yl ether hydrochloride; Amino-PEG1-bis(PEG2-propargyl) HCl salt; Heterobifunctional PEG linker amine-PEG1-bis(propargyl-PEG2); N1-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)-N1-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)ethane-1,2-diamine hydrochloride; Bis(PEG2-propargyl) amine-PEG1 HCl salt; Propargyl-PEG2-amine-PEG1-bis(PEG2-propargyl) HCl
EINECS	Contact for details

Quality Control

Our n-(Amino-Peg1)-n-Bis(Peg2-Propargyl) Hcl Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by titration or NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.