Description

4-Chloro-3-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering enhanced stability and handling properties compared to its free acid form, which is critical for complex multi-step synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex aromatic and heteroaromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated and fluorinated aromatic motifs.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics, via cross-coupling polymerization.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Useful in the construction of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	2098632-65-4
Molecular Formula	C13H15BClF3O3
Molecular Weight	322.52 g/mol
Synonyms	4-Chloro-3-(trifluoromethoxy)benzeneboronic acid pinacol ester; [4-Chloro-3-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 2-[4-Chloro-3-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-α,α,α-trifluoro-3-methoxybenzeneboronic acid pinacol ester; B-[4-Chloro-3-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Chloro-3-(trifluoromethoxy)phenyl)boronic acid pinacol ester; Pinacol 4-Chloro-3-(trifluoromethoxy)phenylboronate
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is characterized by advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to confirm identity, purity, and the absence of critical impurities such as free boronic acid or deprotected species. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term storage or after opening to prevent hydrolysis and maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.