Description

4-Ethynyl-1-[(4-Tetrahydropyranyl)Methyl]Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrazole core functionalized with both ethynyl and tetrahydropyranylmethyl groups. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of targeted small-molecule therapeutics. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, particularly in areas such as kinase inhibition and other enzyme-targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a crucial building block for constructing molecular libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Kinase Inhibitor Development: Used in the research and synthesis of potential kinase inhibitors due to the pyrazole scaffold's affinity for ATP-binding sites.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4-Ethynyl-1-[(4-Tetrahydropyranyl)Methyl]Pyrazole
CAS No.	2098072-57-0
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	1-[(Oxan-4-yl)methyl]-4-ethynyl-1H-pyrazole; 4-Ethynyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-pyrazole; 1-(Tetrahydro-2H-pyran-4-ylmethyl)-4-ethynylpyrazole; 4-Ethynyl-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole; THP-protected ethynyl pyrazole; Pyrazole intermediate 2098072-57-0
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1-[(4-Tetrahydropyranyl)Methyl]Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with research-grade or cGMP standards based on customer project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.