Description

E3 Ligase Ligand-Linker Conjugates 6 is a sophisticated bifunctional chemical tool designed for the targeted degradation of proteins via the PROTAC (Proteolysis Targeting Chimera) technology platform. This compound matters because it enables researchers to specifically eliminate disease-causing proteins by recruiting the cell's own ubiquitin-proteasome system, offering a powerful alternative to traditional inhibition strategies. Pharmaceutical R&D teams and discovery chemists focused on oncology, neurodegenerative diseases, and other challenging therapeutic areas need this high-purity conjugate to develop next-generation targeted protein degraders.

Application

• PROTAC Molecule Development: Serves as a critical building block for synthesizing novel PROTACs aimed at degrading specific protein targets.
• Chemical Biology Research: Used in mechanistic studies to understand E3 ligase engagement, ternary complex formation, and ubiquitination kinetics.
• Drug Discovery Platforms: Integral to high-throughput screening and structure-activity relationship (SAR) studies for targeted protein degradation.
• Oncology Target Validation: Enables the degradation of oncoproteins to validate new cancer targets and assess therapeutic vulnerability.
• Bifunctional Linker Optimization: Provides a model compound for studying the impact of linker chemistry on PROTAC efficacy, selectivity, and cell permeability.
• Preclinical Candidate Synthesis: Used in the synthesis and optimization of lead PROTAC candidates for in vivo evaluation.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 6
CAS No.	2097973-72-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 6; E3 Ligand-Linker 6; Cereblon Ligand-Linker Conjugate; Thalidomide-based PROTAC Linker; (S,R,S)-AHPC-PEG3-C2-Cl; CRBN Recruiting Bifunctional Linker; Degrader Building Block 6; Targeted Protein Degradation Tool Compound
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 6 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive biological assays. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.