Description

Protac Brd9 Degrader-1 is a potent and selective small-molecule degrader designed for targeted protein degradation research. This compound is a critical tool for studying the role of BRD9 in epigenetic regulation and disease pathways, offering a powerful alternative to traditional inhibition. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on oncology, neurodegenerative diseases, and chemical biology.

Application

• Targeted Protein Degradation (TPD) Research: A core chemical probe for validating the PROTAC (Proteolysis Targeting Chimera) technology platform and studying BRD9 biology.
• Epigenetics and Transcriptional Regulation Studies: Used to investigate the functional consequences of BRD9 removal in chromatin remodeling and gene expression.
• Oncology Drug Discovery: Serves as a lead compound or tool for exploring BRD9 as a therapeutic target in various cancers, including AML and synovial sarcoma.
• Mechanism of Action (MOA) Studies: Employed to differentiate between the effects of protein degradation versus simple enzymatic inhibition.
• High-Throughput Screening (HTS) Assay Development: Used as a reference standard in assays designed to discover novel degraders or E3 ligase binders.
• Chemical Biology and Proteomics: A key reagent for understanding protein-protein interactions, ubiquitin-proteasome system dynamics, and cellular signaling networks.

Basic Information

Product Name	Protac Brd9 Degrader-1
CAS No.	2097971-01-0
Molecular Formula	C₃₃H₃₅ClN₆O₆S
Molecular Weight	679.18 g/mol
Synonyms	PROTAC BRD9 Degrader-1; BRD9 Degrader-1; VZ185; (S,R,S)-AHPC-Me; dBET57; (S,R,S)-AHPC-C6-NH-C4-amide-C2-VHL ligand; (2S,4R)-1-((S)-2-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Protac Brd9 Degrader-1 is manufactured under strict quality control protocols to ensure the highest standards of purity and batch-to-batch consistency required for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.