Description

4-(1-Carboxycyclopropyl)-2-Fluorophenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a carboxylic acid moiety for further derivatization. This compound is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the efficient synthesis of complex, fluorinated target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems and cyclopropane motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile coupling partner for the formation of carbon-carbon bonds, enabling the construction of complex biaryl structures under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorophenyl and cyclopropyl groups confer specific biological activity.
• Material Science Research: Employed in the creation of advanced organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, where precise molecular architecture is required.
• Chemical Biology Probes: Acts as a building block for synthesizing molecular probes and inhibitors used to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-(1-Carboxycyclopropyl)-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2096998-21-7
Molecular Formula	C₁₆H₂₀BFO₄
Molecular Weight	306.14 g/mol
Synonyms	2-Fluoro-4-(1-carboxycyclopropyl)phenylboronic acid pinacol ester; [4-(1-Carboxycyclopropyl)-2-fluorophenyl]boronic acid pinacol ester; 4-(1-Carboxycyclopropyl)-2-fluorobenzeneboronic acid pinacol ester; (4-(1-Carboxycyclopropyl)-2-fluorophenyl)boronic acid pinacol ester; Pinacol [4-(1-carboxycyclopropyl)-2-fluorophenyl]boronate; B-[4-(1-Carboxycyclopropyl)-2-fluorophenyl]-5,5-dimethyl-1,3,2-dioxaborinane; 2096998-21-7
EINECS	Contact for details

Quality Control

Our 4-(1-Carboxycyclopropyl)-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee consistency and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.