Description

3-Chloro-2-Fluoro-4-Methoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research institutions and industrial R&D teams in the pharmaceutical and agrochemical sectors for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the introduction of the chloro-fluoro-methoxy phenyl moiety can modulate biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or organic photovoltaics, due to its functional handle for further elaboration.
• Chemical Biology & Probe Development: Utilized as a building block for creating molecular probes and ligands that interact with biological targets, leveraging the boronic acid group's affinity for diols.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for client projects.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-Methoxyphenylboronic Acid
CAS No.	2096454-16-7
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(3-Chloro-2-fluoro-4-methoxyphenyl)boronic acid; 2-Fluoro-3-chloro-4-methoxybenzeneboronic acid; 3-Chloro-2-fluoro-4-methoxybenzeneboronic acid; Boronic acid, B-(3-chloro-2-fluoro-4-methoxyphenyl)-; 2096454-16-7; 3-Chloro-2-fluoro-p-anisylboronic acid; 4-Methoxy-3-chloro-2-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-4-Methoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.