Description

4-Fluoro-2-[(4-Methyl-1-Piperazinyl)Methyl]Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a substituted piperazine moiety that introduces key pharmacophoric features. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery pipelines and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile coupling partner for the formation of carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl scaffolds prevalent in medicinal chemistry.
• Chemical Biology Probe Development: Used to create tagged molecules for studying protein-ligand interactions, enzyme inhibition, and cellular pathway analysis.
• Agrochemical Research: Employed in the discovery and synthesis of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: A building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its conjugated potential.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries to identify new lead structures in drug discovery campaigns.

Basic Information

Product Name	4-Fluoro-2-[(4-Methyl-1-Piperazinyl)Methyl]Phenylboronic Acid Pinacol Ester
CAS No.	2096340-29-1
Molecular Formula	C18H28BFN2O2
Molecular Weight	334.24 g/mol
Synonyms	4-Fluoro-2-((4-methylpiperazin-1-yl)methyl)phenylboronic acid pinacol ester; 2-Fluoro-6-((4-methylpiperazin-1-yl)methyl)phenylboronic acid pinacol ester; (4-Fluoro-2-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid pinacol ester; Pinacol 4-Fluoro-2-((4-methyl-1-piperazinyl)methyl)benzeneboronate; B-[4-Fluoro-2-[(4-methyl-1-piperazinyl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2096340-29-1; 4-Fluoro-2-(4-methylpiperazin-1-ylmethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-[(4-Methyl-1-Piperazinyl)Methyl]Phenylborboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.