Description

2-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial intermediate in modern synthetic organic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a morpholine moiety that offers opportunities for further functionalization. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or requiring fluorinated bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorinated phenyl and morpholine groups can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers, ligands for catalysts, or organic electronic materials.
• Cross-Coupling Reactions: The pinacol-protected boronic ester group is specifically designed for efficient, palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Library Synthesis for High-Throughput Screening: An important reagent for generating diverse compound libraries in medicinal chemistry programs to identify new lead structures.

Basic Information

Product Name	2-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester
CAS No.	2096340-24-6
Molecular Formula	C₁₇H₂₅BFNO₃
Molecular Weight	321.20 g/mol
Synonyms	2-Fluoro-3-(morpholin-4-ylmethyl)phenylboronic acid pinacol ester; [2-Fluoro-3-(morpholinomethyl)phenyl]boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-3-(morpholin-4-ylmethyl)phenyl]-1,3,2-dioxaborolane; 2-(2-Fluoro-3-(morpholinomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[2-fluoro-3-[(4-morpholinyl)methyl]phenyl]-, 1,1-dimethylethyl ester; CAS 2096340-24-6
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Morpholinomethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to quality supports compliance with the stringent requirements of pharmaceutical R&D and other advanced chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.