Description

2-Fluoro-5-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid is a high-purity, multifunctional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in the development of complex molecules, offering unique reactivity due to its combination of fluorine, hydroxyl, and trifluoromethyl substituents. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions and material science applications.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds for next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) due to its unique electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and sensors.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel boron-containing ligands used in asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and specialty chemicals on a commercial scale.

Basic Information

Product Name	2-Fluoro-5-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2096339-99-8
Molecular Formula	C7H5BF4O3
Molecular Weight	223.92 g/mol
Synonyms	[2-Fluoro-5-hydroxy-3-(trifluoromethyl)phenyl]boronic acid; 2-Fluoro-5-hydroxy-3-trifluoromethylbenzeneboronic acid; 2-Fluoro-5-hydroxy-alpha,alpha,α-trifluoro-m-tolylboronic acid; (2-Fluoro-5-hydroxy-3-(trifluoromethyl)phenyl)boronic acid; B-[2-Fluoro-5-hydroxy-3-(trifluoromethyl)phenyl]boronic acid; 2096339-99-8; 3-Borono-5-fluoro-4-hydroxybenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Hydroxy-3-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, this material should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and kept away from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.