Description

3,5-Difluoro-4-Methoxy-2-Methylphenylboronic Acid is a high-value, multi-functional boronic acid derivative used as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential reagent for constructing complex molecules via cross-coupling reactions, particularly in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, material science, and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid partner for forming carbon-carbon bonds with aryl/heteroaryl halides, enabling the construction of complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and methoxy groups for enhanced bioactivity and metabolic stability.
• Material Science & OLED Development: Employed in the creation of organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Design: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Development: Utilized in the design of molecular probes and sensors for studying biological processes, benefiting from its boronic acid group's affinity for diols.

Basic Information

Product Name	3,5-Difluoro-4-Methoxy-2-Methylphenylboronic Acid
CAS No.	2096338-65-5
Molecular Formula	C9H11BF2O3
Molecular Weight	216.00 g/mol
Synonyms	(3,5-Difluoro-4-methoxy-2-methylphenyl)boronic acid; 2-Methyl-3,5-difluoro-4-methoxybenzeneboronic acid; B-(3,5-Difluoro-4-methoxy-2-methylphenyl)boronic acid; 3,5-Difluoro-4-methoxy-o-tolylboronic acid; 2096338-65-5; Boronic acid, B-(3,5-difluoro-4-methoxy-2-methylphenyl)-; 4-Methoxy-3,5-difluoro-2-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxy-2-Methylphenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and LC-MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.