Description

n-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopropanamine CAS NO 2096338-43-9 is a high-value, advanced pharmaceutical intermediate featuring a cyclopropylamine group and a pinacol boronate ester. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is an essential building block for medicinal chemists and R&D teams in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation to create complex biaryl structures.
• Medicinal Chemistry & Drug Discovery: Used extensively in lead optimization and library synthesis to explore structure-activity relationships (SAR) by introducing the cyclopropanamine and fluorinated aryl motifs.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Potential monomer or precursor for advanced organic electronic materials and liquid crystals due to its rigid, conjugated structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences sector.

Basic Information

Product Name	n-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopropanamine
CAS No.	2096338-43-9
Molecular Formula	C16H23BFNO2
Molecular Weight	291.17 g/mol
Synonyms	1-[(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]cyclopropanamine; N-[(4-Fluoro-3-(pinacolboryl)benzyl]cyclopropanamine; 4-Fluoro-3-(pinacolboryl)benzylcyclopropylamine; 2-(4-((Aminomethyl)cyclopropyl)methyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclopropanamine, N-[[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-; CAS 2096338-43-9
EINECS	Contact for details

Quality Control

Every batch of n-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopropanamine is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards required for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.