Description

3-Nitro-5-Trifluoromethylphenyl Boronicacid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid building block, enabling advanced cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules containing trifluoromethyl and nitro-substituted aromatic systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the nitro and trifluoromethyl groups contribute to biological activity and selectivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its specific aromatic structure can tune electronic properties.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds under mild conditions.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3-Nitro-5-Trifluoromethylphenyl Boronicacid Pinacol Ester
CAS No.	2096337-98-1
Molecular Formula	C₁₃H₁₅BF₃NO₄
Molecular Weight	317.07 g/mol
Synonyms	[3-Nitro-5-(trifluoromethyl)phenyl]boronic acid pinacol ester; Pinacol [3-Nitro-5-(trifluoromethyl)phenyl]boronate; 3-Nitro-5-(trifluoromethyl)benzeneboronic acid pinacol ester; 5-Trifluoromethyl-3-nitrophenylboronic acid pinacol ester; (3-Nitro-5-trifluoromethylphenyl)boronic acid pinacol ester; Boronic acid, B-[3-nitro-5-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Nitro-5-Trifluoromethylphenyl Boronicacid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.