Description

2-[4-Bromo-2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block critical for modern synthetic chemistry. This compound is essential for facilitating efficient Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex, fluorinated aromatic scaffolds. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with fluorinated and trifluoromethylated aromatic cores, enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated and fluorinated phenyl groups.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for imaging and diagnostic applications due to its versatile coupling handle.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-[4-Bromo-2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096337-75-4
Molecular Formula	C13H14BBrF4O2
Molecular Weight	369.96 g/mol
Synonyms	4-Bromo-2-fluoro-5-(trifluoromethyl)benzeneboronic acid pinacol ester; (4-Bromo-2-fluoro-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(4-Bromo-2-fluoro-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Bromo-2-fluoro-5-trifluoromethylphenylboronic acid pinacol ester; Pinacol [4-Bromo-2-fluoro-5-(trifluoromethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of 2-[4-Bromo-2-Fluoro-5-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.