Description

2-[2-Fluoro-5-Nitro-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex fluorinated aromatic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. The CAS number for this product is 2096336-43-3.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitro-substituted aromatic rings for enhanced bioavailability and metabolic stability.
• Agrochemical Research: Used to create novel herbicides, fungicides, and insecticides where the specific substitution pattern can confer unique biological activity and selectivity.
• Material Science: Building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where fluorinated units improve charge transport and stability.
• Chemical Synthesis: A versatile reagent in Suzuki-Miyaura cross-coupling reactions for the precise formation of carbon-carbon bonds in complex molecule assembly.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Life Science Probes: Potential use in developing fluorescent tags or molecular probes for imaging and diagnostic applications due to its functionalizable aromatic core.

Basic Information

Product Name	2-[2-Fluoro-5-Nitro-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096336-43-3
Molecular Formula	C₁₃H₁₄BF₄NO₄
Molecular Weight	335.06 g/mol
Synonyms	2-Fluoro-5-nitro-3-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Fluoro-5-nitro-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(2-Fluoro-5-nitro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [2-fluoro-5-nitro-3-(trifluoromethyl)phenyl]boronate; 2096336-43-3; Boronic acid, B-[2-fluoro-5-nitro-3-(trifluoromethyl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-[2-Fluoro-5-Nitro-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.