Description

3-Fluror-5-(2-Methylpiperidine-L-Carbonyl)Benzeneboronic Acid is a sophisticated boronic acid derivative, a key building block in modern synthetic organic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated aromatic system and a chiral 2-methylpiperidine moiety, enabling the construction of complex, stereodefined molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, due to its chiral piperidine structure.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atom and boronic acid group impart specific biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in medicinal chemistry.
• Ligand and Catalyst Development: The chiral center makes it a valuable starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic systems are advantageous.
• Chemical Biology & Proteomics: Can be utilized as a handle for bioconjugation or in the development of chemical probes and inhibitors for studying enzyme function.

Basic Information

Product Name	3-Fluror-5-(2-Methylpiperidine-L-Carbonyl)Benzeneboronic Acid
CAS No.	2096336-16-0
Molecular Formula	C14H19BFNO3
Molecular Weight	279.12 g/mol
Synonyms	[3-Fluoro-5-[(2S)-2-methylpiperidine-1-carbonyl]phenyl]boronic acid; (3-Fluoro-5-((S)-2-methylpiperidine-1-carbonyl)phenyl)boronic acid; 3-Fluoro-5-[(2S)-2-methyl-1-piperidinyl]carbonylbenzeneboronic acid; Boronic acid, B-[3-fluoro-5-[(2S)-2-methyl-1-piperidinyl]carbonyl]phenyl]-; 2096336-16-0; (S)-3-Fluoro-5-(2-methylpiperidine-1-carbonyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Fluror-5-(2-Methylpiperidine-L-Carbonyl)Benzeneboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and process chemistry. Our quality control protocols include advanced chromatographic and spectroscopic methods to verify identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), chiral purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.