Description

4-Ethoxy-3,5-Difluoro-2-Methylphenylboronic Acid is a specialized organoboron compound, specifically a substituted phenylboronic acid, serving as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific fluorinated and ethoxy-substituted aromatic systems.
• Material Science Research: Building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics, where its structure can influence charge transport properties.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors that leverage boronic acid-diol interactions for detection and binding studies.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Ethoxy-3,5-Difluoro-2-Methylphenylboronic Acid
CAS No.	2096335-57-6
Molecular Formula	C10H13BF2O3
Molecular Weight	230.02 g/mol
Synonyms	(4-Ethoxy-3,5-difluoro-2-methylphenyl)boronic acid; 2-Methyl-4-ethoxy-3,5-difluorophenylboronic acid; 3,5-Difluoro-4-ethoxy-2-methylbenzeneboronic acid; Boronic acid, B-(4-ethoxy-3,5-difluoro-2-methylphenyl)-; 2096335-57-6; 4-Ethoxy-3,5-difluoro-o-tolylboronic acid
EINECS	Contact for details

Quality Control

Our production of 4-Ethoxy-3,5-Difluoro-2-Methylphenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical R&D. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.