Description

5-Ethoxy-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid is a high-purity, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for new drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct novel herbicide and pesticide molecules with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential reagent for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Chemical Biology & Probe Development: Employed in creating molecular probes and diagnostic agents for biological target identification and validation.
• Scale-Up Process Chemistry: Suitable for use in pilot plant and commercial-scale manufacturing of fine chemicals under GMP conditions.

Basic Information

Product Name	5-Ethoxy-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2096332-76-0
Molecular Formula	C9H9BF4O3
Molecular Weight	251.98 g/mol
Synonyms	2-Fluoro-5-ethoxy-3-(trifluoromethyl)benzeneboronic acid; (5-Ethoxy-2-fluoro-3-(trifluoromethyl)phenyl)boronic acid; 5-Ethoxy-2-fluoro-α,α,α-trifluoro-m-tolylboronic acid; Boronic acid, B-[5-ethoxy-2-fluoro-3-(trifluoromethyl)phenyl]-; 2096332-76-0; 5-Ethoxy-2-fluoro-3-trifluoromethylphenylboronic acid; 2-Fluoro-5-ethoxy-3-trifluoromethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our 5-Ethoxy-2-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.