Description

2-(3-Bromo-5-Chloro-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, multi-halogenated phenylboronic acid pinacol ester, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED displays and lighting.
• Ligand & Catalyst Design: Employed in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric synthesis and polymerization processes.
• Chemical Biology & Probe Development: Utilized to create molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Polymer & Specialty Chemical Manufacturing: Acts as a monomer or modifier in the synthesis of high-performance polymers and specialty chemicals with unique thermal or optical properties.

Basic Information

Product Name	2-(3-Bromo-5-Chloro-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096332-53-3
Molecular Formula	C12H14BBrClFO2
Molecular Weight	349.40 g/mol
Synonyms	3-Bromo-5-Chloro-4-Fluorophenylboronic Acid Pinacol Ester; (3-Bromo-5-Chloro-4-Fluorophenyl)boronic Acid Pinacol Ester; 2-(3-Bromo-5-Chloro-4-Fluorophenyl)-1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-; (3-Br-5-Cl-4-F-C6H)Bpin; B-(3-Bromo-5-Chloro-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane; Pinacol (3-Bromo-5-Chloro-4-Fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Chloro-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive analytical data, including HPLC purity, NMR (1H, 13C, 19F, 11B) confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.