Description

2-Bromo-n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold combining a bromoacetamide moiety with a protected boronic acid ester (pinacol boronate). This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing biaryl and heterobiaryl systems. It is an essential building block for researchers and manufacturers in pharmaceutical R&D and agrochemical synthesis who require reliable, high-quality precursors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other protein-protein interactions.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides, facilitating library synthesis and lead optimization.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific biaryl structural motifs.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic electronic materials and advanced polymers.
• Chemical Biology & Proteomics: Can be utilized as a warhead or linker in the design of activity-based probes and covalent inhibitors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	2-Bromo-n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	2096331-74-5
Molecular Formula	C16H23BBrNO3
Molecular Weight	368.08 g/mol
Synonyms	2-Bromo-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-bromoacetamide; 3-(2-Bromoacetamido)phenylboronic acid pinacol ester; 2-Bromoacetamide, N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Bromoacetamide Boronic Ester; 2096331-74-5; Boronic acid, B-[3-[(2-bromoacetyl)amino]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and LC-MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with complete analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.