Description

2,4-Difluoro-5-Hydroxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its unique structure, featuring both hydroxyl and boronic acid groups on a difluorinated aromatic ring, makes it a versatile and critical building block for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical researchers and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and stability.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, sensors, and inhibitors that target specific enzymes or biological pathways.
• Catalyst Ligand Development: The boronic acid and phenolic hydroxyl groups can be utilized to create novel ligands for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research programs.

Basic Information

Item	Details
Product Name	2,4-Difluoro-5-Hydroxyphenylboronic Acid
CAS No.	2096330-91-3
Molecular Formula	C6H5BF2O3
Molecular Weight	173.92 g/mol
Synonyms	(5-Hydroxy-2,4-difluorophenyl)boronic acid; 2,4-Difluoro-5-hydroxybenzeneboronic acid; 5-Hydroxy-2,4-difluorophenylboronic acid; Boronic acid, B-(5-hydroxy-2,4-difluorophenyl)-; 2,4-Difluoro-5-hydroxybenzeneboronic acid pinacol ester (common derivative); 5-Hydroxy-2,4-difluoro phenyl boronic acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and elemental analysis to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring material that meets ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.