Description

2,3-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its stability and reactivity as a protected boronic acid, enabling critical carbon-carbon bond formation in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing new active ingredients via Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing difluoromethoxy phenyl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable organoboron reagent for palladium-catalyzed coupling reactions to create biaryl structures, a fundamental step in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and functional materials.
• Material Science: A precursor for creating organic electronic materials and liquid crystals where fluorination tunes electronic properties and stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and drug discovery.

Basic Information

Product Name	2,3-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	2096330-29-7
Molecular Formula	C₁₃H₁₇BF₂O₃
Molecular Weight	270.08 g/mol
Synonyms	2,3-Difluoro-5-methoxyphenylboronic acid pinacol ester; 5-Methoxy-2,3-difluorophenylboronic acid pinacol ester; 2-(2,3-Difluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,3-Difluoro-5-methoxybenzeneboronic acid pinacol ester; Pinacol (2,3-difluoro-5-methoxyphenyl)boronate; (2,3-Difluoro-5-methoxyphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Methoxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.