Description

n-Boc-n-Bis(Peg4-Acid) CAS NO 2093152-88-4 is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a tert-butoxycarbonyl (Boc) protecting group and terminal carboxylic acid functionalities. This compound is engineered as a critical building block for the synthesis of complex molecular architectures, particularly in the development of advanced drug delivery systems and bioconjugates. Its primary value lies in providing a precisely controlled, hydrophilic spacer arm that enhances solubility and reduces immunogenicity. Pharmaceutical researchers, biotech companies, and advanced material scientists require this high-purity intermediate for creating next-generation therapeutics, including antibody-drug conjugates (ADCs), peptide therapeutics, and hydrogel networks.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a core component for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein PEGylation: Used to modify peptides and proteins to improve their pharmacokinetic profile, stability, and solubility.
• Dendrimer and Polymer Synthesis: Acts as a branching unit or monomer in the creation of well-defined, biocompatible dendritic polymers and hydrogels for controlled release.
• Diagnostic Probe Conjugation: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting molecules like antibodies or peptides.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and other material surfaces with carboxylic acid groups for further bioconjugation.
• Prodrug Development: Utilized to create solubilizing linkers that connect active drug molecules to promoieties, which are cleaved under specific physiological conditions.

Basic Information

Product Name	n-Boc-n-Bis(Peg4-Acid)
CAS No.	2093152-88-4
Molecular Formula	C29H54N2O15
Molecular Weight	670.75 g/mol
Synonyms	1,11-Bis(2-{2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]ethoxy}acetic acid); Boc-NH-PEG4-CH2CH2-COOH (dimer); tert-Butyl (bis(2-(2-(2-(2-carboxyethoxy)ethoxy)ethoxy)ethyl)carbamate; Bifunctional PEG4 Acid Boc-Protected; Boc-Amine-PEG4-Acid (Bifunctional); 2,2'-(2,2'-(2,2'-(2,2'-(2,2'-(2,2'-(Bis(2-((tert-butoxycarbonyl)amino)ethyl)azanediyl)bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))diacetic acid
EINECS	Contact for details

Quality Control

Our n-Boc-n-Bis(Peg4-Acid) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and KF titration for moisture content. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development protocols. Specifications are designed to meet the stringent requirements of pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.