Description

n-(Amino-Peg5)-n-Bis(Peg4-Acid) CAS NO 2093152-86-2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and two carboxylic acid termini, connected via defined PEG spacers. This trifunctional architecture is critical for creating sophisticated bioconjugates and cross-linked materials with precise control over spacing and solubility. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require advanced, water-soluble linkers for drug delivery systems, diagnostic reagents, and hydrogel formation.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional cross-linker for attaching peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules, leveraging its amine-reactive and carboxyl-reactive ends.
• Drug Delivery System Development: Used to create PEGylated prodrugs or to functionalize liposomes and polymeric nanoparticles, enhancing circulation time and targeting specificity.
• Diagnostic Reagent Synthesis: Employed in the preparation of fluorescent or enzyme-labeled probes and immunoassay components due to its ability to introduce multiple functional groups.
• Hydrogel and Biomaterial Fabrication: Acts as a key monomer or cross-linking agent for synthesizing PEG-based hydrogels with tunable mechanical properties and degradation profiles for tissue engineering.
• Surface Modification: Facilitates the creation of functionalized surfaces with amine or carboxyl groups for subsequent immobilization of biomolecules in biosensor and microarray technologies.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Provides a PEG spacer to connect cytotoxic drugs to antibodies, optimizing the stability and pharmacokinetics of the ADC.

Basic Information

Product Name	n-(Amino-Peg5)-n-Bis(Peg4-Acid)
CAS No.	2093152-86-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,2',2''',2'''',2'''''-((((2-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethoxy)ethyl)azanediyl)bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))tetraacetic acid; Amino-PEG5-tris-(PEG4-acid); Heterotrifunctional PEG, Amine, bis-Carboxyl; 15-Amino-4,7,10,13-tetraoxapentadecanoic acid, 1,1'-[iminobis(2,1-ethanediyloxy-4,1-butanediyl)] ester; NH2-PEG5-(COOH)2; PEG-based Trifunctional Crosslinker
EINECS	Contact for details

Quality Control

Our n-(Amino-Peg5)-n-Bis(Peg4-Acid) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR and MS for structural confirmation, and functional group titration, to ensure it meets the high standards required for research and bioconjugation applications. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Amine Value (Titration)	Contact for details
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.