Description

n-(Mal-Peg6)-n-Bis(Peg7-Tco) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and two trans-cyclooctene (TCO) groups, enabling orthogonal, site-specific bioconjugation. This compound is critical for advanced bioconjugation strategies, offering controlled, multi-step labeling of biomolecules with high efficiency and minimal cross-reactivity. It is primarily needed by researchers and developers in biopharmaceuticals, diagnostic assay development, and advanced materials science for creating complex therapeutic conjugates, imaging probes, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker: For constructing dual-payload or branched ADC architectures via sequential click chemistry and thiol-maleimide coupling.
• Multi-modal Imaging Probe Synthesis: Enables the attachment of different contrast agents (e.g., fluorescent dyes, chelators for radiolabels) to a single targeting molecule.
• Surface Functionalization: For creating multi-ligand or patterned surfaces on chips, nanoparticles, or beads for biosensing and capture applications.
• Protein and Peptide PEGylation: Facilitates site-specific, branched PEGylation to improve pharmacokinetic properties while maintaining bioactivity.
• Hydrogel Formation: Acts as a crosslinking agent for creating bio-orthogonal, tunable hydrogel networks for 3D cell culture and drug delivery.
• Diagnostic Assay Development: Used to create complex, multi-component detection systems with amplified signals.

Basic Information

Product Name	n-(Mal-Peg6)-n-Bis(Peg7-Tco)
CAS No.	2093152-84-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG6-Bis(TCO-PEG7); TCO-PEG7-Mal-PEG6-Bis(TCO-PEG7); Heterobifunctional PEG Crosslinker Mal-PEG6-Bis(TCO-PEG7); 1,1'-(Mal-PEG6)-1,1'-Bis(TCO-PEG7); n-(3-Maleimidopropionyl-PEG6)-n-Bis(trans-Cyclooctene-PEG7); TCO-PEG7-Maleimide-PEG6-Bis(TCO-PEG7); Bifunctional PEG Reagent 2093152-84-0; Mal-PEG6-Bis(TCO-PEG7) Crosslinker
EINECS	Contact for details

Quality Control

Our n-(Mal-Peg6)-n-Bis(Peg7-Tco) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure consistency and performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Maleimide)	≥ 90% of theoretical
Functional Group Assay (TCO)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.