Description

n-(Azido-Peg4)-n-Bis(Peg4-Acid) Hcl Salt CAS NO 2093152-80-6 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and two carboxylic acid termini, presented as its hydrochloride salt. This compound is engineered for high-efficiency bioconjugation, enabling the stable and site-specific coupling of biomolecules via click chemistry and amide bond formation. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, particularly for creating PEGylated therapeutics, diagnostic probes, and functionalized hydrogels.

Application

• Bioconjugation and PEGylation of therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Synthesis of antibody-drug conjugates (ADCs) using the azide group for copper-free click chemistry with alkyne-modified payloads.
• Functionalization of nanoparticles and surfaces for biosensing and targeted drug delivery applications.
• Crosslinking agent in hydrogel formation for tissue engineering and 3D cell culture scaffolds.
• Preparation of diagnostic reagents and imaging probes by conjugating targeting ligands with reporter molecules.
• Solid-phase peptide synthesis (SPPS) as a versatile linker for introducing PEG spacers.
• Modification of oligonucleotides to improve nuclease resistance and cellular uptake.

Basic Information

Item	Detail
Product Name	n-(Azido-Peg4)-n-Bis(Peg4-Acid) Hcl Salt
CAS No.	2093152-80-6
Molecular Formula	C33H62N4O17 • HCl
Molecular Weight	823.3 g/mol (free base)
Synonyms	Azido-PEG4-Bis(PEG4-acid) HCl Salt; 1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid, 15-[(1-oxo-2,5,8,11-tetraoxatetradecan-14-yl)oxy]-, hydrochloride; N3-PEG4-Bis(PEG4-COOH) HCl; Heterobifunctional PEG Crosslinker, Azide and Acid; 15-Azido-4,7,10,13-tetraoxa-16-azahenicosanedioic acid, 1,21-diethyl ester, hydrochloride; Azido-PEG4-tetraacetic acid HCl Salt; PEG-based Azido Acid Crosslinker
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg4)-n-Bis(Peg4-Acid) Hcl Salt is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioproduction. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.