Description

Propargyl-Peg7-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and an NHS ester for efficient amine conjugation. This compound is essential for creating stable, hydrophilic spacers in bioconjugation, enabling the precise assembly of complex biomolecular architectures. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science for constructing antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Serves as a critical linker for attaching cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via its orthogonal click chemistry and amine-reactive functionalities.
• Proteomics and Biomarker Research: Used to label and cross-link biomolecules for mass spectrometry analysis, pull-down assays, and the study of protein-protein interactions.
• Polymer and Materials Science: Acts as a functional monomer or cross-linker for synthesizing smart hydrogels, surface coatings, and drug delivery systems with tailored hydrophilicity and reactivity.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic kits and biosensors by conjugating recognition elements (e.g., antibodies, enzymes) to signal-generating molecules or solid supports.
• Click Chemistry Toolbox: A fundamental reagent for CuAAC reactions in chemical biology, enabling rapid and high-yielding ligation of diverse molecular components under aqueous conditions.
• Nanoparticle Functionalization: Facilitates the surface modification of nanoparticles (e.g., liposomes, quantum dots, polymeric NPs) for targeted drug delivery and imaging applications.

Basic Information

Product Name	Propargyl-Peg7-Nhs Ester
CAS No.	2093152-77-1
Molecular Formula	C31H53NO14
Molecular Weight	663.75 g/mol
Synonyms	Propargyl-PEG7-NHS ester; NHS-PEG7-Alkyne; N-Hydroxysuccinimide ester of Propargyl-PEG7-acid; Alkyne-PEG7-NHS; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21-heptaoxatetratriacont-33-yn-1-oate; Propargyl-PEG7-OSu; Click Chemistry PEG NHS Ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg7-Nhs Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90% (NHS ester)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.