Description

(±)-Pomalidomide-D3(Phthalimide-4,5,6-D3) is a deuterated isotopologue of the immunomodulatory drug pomalidomide, specifically labeled at the 4, 5, and 6 positions of the phthalimide ring. This compound is essential as a high-purity internal standard for the accurate quantification of pomalidomide in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and bioanalytical service providers engaged in pharmacokinetic studies, drug metabolism research, and clinical trial support for multiple myeloma treatments.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound for the precise and accurate quantification of pomalidomide in plasma, serum, and tissue samples via mass spectrometry.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used to investigate metabolic pathways and identify metabolites without interference from endogenous compounds.
• Clinical Trial Support: Provides essential data integrity for therapeutic drug monitoring and efficacy assessments during clinical development phases.
• Method Development and Validation: A key component in establishing and validating robust, regulatory-compliant (FDA/EMA) bioanalytical methods.
• Stability-Indicating Assays: Helps in developing assays to monitor the stability and degradation products of pomalidomide in formulations.

Basic Information

Product Name	(±)-Pomalidomide-D3(Phthalimide-4,5,6-D3)
CAS No.	2093128-28-8
Molecular Formula	C₁₃H₈D₃N₃O₄
Molecular Weight	274.27 g/mol
Synonyms	Pomalidomide-d3; 4-Aminophthalimidoglutarimide-d3; CC-4047-d3; Actimid-d3; (RS)-Pomalidomide-d3; 3-(4-Amino-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxopiperidine-4,5,6-d3; (R,S)-4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione-4,5,6-d3
EINECS	Contact for details

Quality Control

Every batch of our (±)-Pomalidomide-D3(Phthalimide-4,5,6-D3) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative bioanalysis. Comprehensive testing includes assay, isotopic enrichment (D-content), and identification of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications and traceability to reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.