Description

Benzonitrile, 4-Amino-3-Chloro-2-Fluoro- CAS NO 2092765-25-6 is a high-purity, multi-substituted aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique combination of amino, chloro, fluoro, and cyano functional groups makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antibacterial agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its halogenated structure contributes to biological activity.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its aromatic core and polar nitrile group.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes, tags, and linkers for studying biological systems.
• Dye and Pigment Intermediate: Utilized in the development of specialized colorants and functional dyes.
• Cross-Coupling Reactions: The cyano and halogen groups make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).

Basic Information

Product Name	Benzonitrile, 4-Amino-3-Chloro-2-Fluoro-
CAS No.	2092765-25-6
Molecular Formula	C7H4ClFN2
Molecular Weight	170.57 g/mol
Synonyms	4-Amino-3-chloro-2-fluorobenzonitrile; 3-Chloro-2-fluoro-4-aminobenzonitrile; 2-Fluoro-4-amino-3-chlorobenzonitrile; 4-Amino-2-fluoro-3-chlorobenzonitrile; 2-Fluoro-3-chloro-4-cyanobenzeneamine; Benzonitrile, 4-amino-3-chloro-2-fluoro-; 4-Cyano-2-fluoro-3-chloroaniline
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Amino-3-Chloro-2-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) are provided with every shipment, detailing purity, identity, and impurity profiles. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.