Description

8-(Trifluoromethoxy)Quinolin-3-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline scaffold substituted with a trifluoromethoxy group and an amine functionality. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular properties. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective research.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the biological activity of the quinoline core.
• Material Science: Serves as a precursor for functionalized organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic compounds and exploring structure-activity relationships (SAR).
• Fluorinated Compound Libraries: An essential reagent for creating focused libraries of fluorinated molecules, a critical strategy in modern medicinal chemistry to optimize drug-like properties.

Basic Information

Product Name	8-(Trifluoromethoxy)Quinolin-3-Amine
CAS No.	2092339-50-7
Molecular Formula	C₁₀H₇F₃N₂O
Molecular Weight	228.17 g/mol
Synonyms	3-Amino-8-(trifluoromethoxy)quinoline; 8-(Trifluoromethoxy)-3-quinolinamine; Quinolin-3-amine, 8-(trifluoromethoxy)-; 8-Trifluoromethoxyquinolin-3-ylamine; 2092339-50-7; 8-(Trifluoromethoxy)-3-aminoquinoline; 3-Amino-8-trifluoromethoxyquinoline
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethoxy)Quinolin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.