Description

trans-3-(Trifluoromethyl)Cyclobutanol CAS NO 2091782-60-2 is a high-value, fluorinated cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group on a strained cyclobutane ring, is essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Material Science: Investigated as a monomer or additive for specialty polymers and liquid crystals, imparting unique electronic and surface properties.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity and stereochemistry of fluorinated cyclobutane rings in academic and industrial R&D settings.

Basic Information

Product Name	trans-3-(Trifluoromethyl)Cyclobutanol
CAS No.	2091782-60-2
Molecular Formula	C5H7F3O
Molecular Weight	140.11 g/mol
Synonyms	trans-3-(Trifluoromethyl)cyclobutan-1-ol; (1r,3r)-3-(Trifluoromethyl)cyclobutanol; rel-(1R,3R)-3-(Trifluoromethyl)cyclobutan-1-ol; 3-(Trifluoromethyl)cyclobutanol (trans-); FC-0322; BCP 32212; AKH 00000355
EINECS	Contact for details

Quality Control

Our trans-3-(Trifluoromethyl)Cyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.