Description

(S)-3,3-Difluorocyclopentan-1-Ol is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. This compound matters because its unique stereochemistry and difluoromethylene group are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in the development of enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology, CNS, and metabolic disease areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorinated cyclopentane scaffold enhances bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties.
• Medicinal Chemistry Probe: Utilized to introduce conformational restraint and fluorine atoms into lead compounds during structure-activity relationship (SAR) studies.

Basic Information

Product Name	(S)-3,3-Difluorocyclopentan-1-Ol
CAS No.	2091355-24-5
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	(1S)-3,3-Difluorocyclopentan-1-ol; (S)-3,3-Difluorocyclopentanol; (S)-3,3-Difluorocyclopentyl alcohol; (S)-1-Hydroxy-3,3-difluorocyclopentane; (S)-3,3-Difluorocyclopentane-1-ol; 2091355-24-5; (S)-3,3-Difluoro-1-cyclopentanol
EINECS	Contact for details

Quality Control

Our (S)-3,3-Difluorocyclopentan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and GC/HPLC for chemical purity, to ensure it meets the high standards required for advanced R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.