Description

6-Ethynyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazine is a high-value, heterocyclic organic building block featuring a fused pyrido-oxazine core with a terminal ethynyl group. This compound matters as a critical synthetic intermediate, enabling the construction of complex molecular architectures through versatile click chemistry and cross-coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in kinase inhibitor and other small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and plant growth regulators.
• Material Science: Monomer or cross-linker for advanced polymers and functional materials via its reactive alkyne group.
• Chemical Biology: Probe development for bio-conjugation and labeling applications using click chemistry (e.g., CuAAC).
• Organic Synthesis: Versatile scaffold for constructing complex nitrogen- and oxygen-containing heterocycles through Sonogashira and other palladium-catalyzed couplings.

Basic Information

Product Name	6-Ethynyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazine
CAS No.	2090929-24-9
Molecular Formula	C9H8N2O
Molecular Weight	160.17 g/mol
Synonyms	6-Ethynyl-1,4-dihydropyrido[2,3-b][1,4]oxazine; 6-Ethynyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine; 2090929-24-9; 6-Ethynyl-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazine; 1,4-Dihydropyrido[2,3-b][1,4]oxazine, 6-ethynyl-; 6-Ethynyl-2,3-dihydro-1H-pyrido[2,3-b]oxazine
EINECS	Contact for details

Quality Control

Our 6-Ethynyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications. We support cGMP and ISO compliant production for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to prevent potential oxidation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.