Description

n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide is a sophisticated chiral phosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly selective and efficient chemical transformations, which are essential for producing enantiomerically pure intermediates in pharmaceutical and fine chemical synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel synthetic routes and optimizing production processes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in asymmetric C-C bond-forming reactions (e.g., cross-coupling, allylic alkylation).
• Key reagent for the enantioselective synthesis of complex organic molecules in academic and industrial research.
• Use in the development of high-performance catalytic systems for the production of agrochemicals and flavors/fragrances.
• Critical material for process chemistry optimization in GMP manufacturing environments.
• Research tool for exploring new asymmetric catalytic methodologies in chemical discovery.

Basic Information

Product Name	n-[(1S)-1-[3',5'-Bis(1,1-Dimethylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide
CAS No.	2089424-11-1
Molecular Formula	C55H56F6NOP
Molecular Weight	891.99 g/mol
Synonyms	(S)-3,5-Bis(trifluoromethyl)-N-[1-[3',5'-di-tert-butyl-[1,1'-biphenyl]-2-yl]-2-(diphenylphosphanyl)ethyl]benzamide; (S)-3,5-Bis(trifluoromethyl)-N-[1-[3',5'-di-tert-butylbiphenyl-2-yl]-2-(diphenylphosphino)ethyl]benzamide; Chiral Phosphine-Benzamide Ligand; Asymmetric Hydrogenation Ligand; DTBM-SEGPHOS Amide Derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. Due to its sensitivity to oxidation and light, the container should only be opened in an inert environment and handled promptly to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.