Description

n-[(1S)-1-[1,1'-Biphenyl]-2-Yl-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide is a sophisticated chiral phosphine ligand, a key class of compounds in modern asymmetric catalysis. Its value lies in enabling highly selective and efficient chemical transformations, which are critical for producing enantiomerically pure pharmaceuticals and fine chemicals. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic routes.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and hydroformylation.
• Critical component in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and drug intermediates.
• Use in the development of novel catalytic systems for academic and industrial research in organic synthesis.
• Potential application in the asymmetric synthesis of agrochemicals and specialty chemicals.
• Employed as a key building block for creating more complex, tailored ligand architectures.

Basic Information

Product Name	n-[(1S)-1-[1,1'-Biphenyl]-2-Yl-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide
CAS No.	2089424-10-0
Molecular Formula	C39H28F6NOP
Molecular Weight	671.61 g/mol
Synonyms	(S)-BIPHEP-Benzamide Derivative; (S)-2-(Diphenylphosphino)-2'-(3,5-bis(trifluoromethyl)benzamido)-1,1'-biphenyl; (S)-[2-(Diphenylphosphino)-[1,1'-biphenyl]-2-yl]-3,5-bis(trifluoromethyl)benzamide; (S)-Benzamide, N-[1-[1,1'-biphenyl]-2-yl-2-(diphenylphosphino)ethyl]-3,5-bis(trifluoromethyl)-; Chiral Biphenyl Phosphine Ligand; (S)-TRIPHOS-Benzamide Ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-[(1S)-1-[1,1'-Biphenyl]-2-Yl-2-(Diphenylphosphino)Ethyl]-3,5-Bis(Trifluoromethyl)-Benzamide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chiral purity, which is paramount for catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess. We adhere to cGMP principles where applicable to support pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.